Shop / Elanco Flea & Tick Topical Treatments / Advantage II Large Dog Vet-Recommended Flea Treatment & Prevention | Dogs 21-55 lbs. Advantage II Advantage II Large Dog Vet-Recommended Flea Treatment & Prevention | Dogs 21-55 lbs. 4 Month Dose $50.99 4 Month Dose Purchase Options Free In-Store Pick Up Not Available Set your store for inventory and store pickup details Zip Code Search Same-day Delivery* No minimum charge for delivery orders. *Order before 2pm and have it delivered today. Orders placed after 2pm will be delivered the next day. Must be inside delivery radius. Zip Code Unfortunately delivery is not available to this address. In order to ensure the best availability accuracy, changing your selected store will remove all items from your cart. You will need to re-add these items with your newly selected store if you choose to continue. Continue Cancel Ship it to Me Not Available Quantity Add To Cart Information Deliver total flea protection to your dog or puppy with Advantage II Large Dog. This vet-recommended, topical treatment and prevention formula kills adult fleas, flea larvae, and flea eggs on contact within 12 hours of application - meaning fleas can be eliminated before they bite or lay new eggs. Effectively break the flea life cycle, control existing flea and lice infestations, and prevent further infestations with one simple application. Advantage II Large Dog flea and lice protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh 21-55 lbs. to use Advantage II Large Dog. Advantage II Large Dog is a trademark of Elanco or its affiliates. Key Features Vet recommended flea treatment and prevention for dogs at weighing 21 to 55 lbs., at least 7 weeks of age Kills adult fleas, flea larvae and flea eggs for total flea prevention and treatment Same-day effectiveness, kills fleas within 12 hours of application and keeps working for 30 days Easy-to-apply topical treatment, no prescription needed Fragrance-free formula, waterproof after 24 hours Customers also liked Customer Reviews